WebJan 16, 2024 · Rhabdomyolysis means dissolution of skeletal muscle, and it is characterized by leakage of muscle cell contents, myoglobin, sarcoplasmic proteins (creatine kinase, lactate dehydrogenase, aldolase, … WebDec 13, 2024 · Conclusion The combined use of daptomycin and statins were significant risk factors for the incidence of CPK elevation defined as levels ≥ULN or ≥5× ULN and rhabdomyolysis. COMPETING INTERESTS The authors declare that they do not have any …
Evaluation of Daptomycin-Induced Cellular Membrane ... - 日 …
WebRhabdomyolysis is a known possible complication associated with daptomycin therapy. However, previous findings were predominantly in phase 1 and 2 trials, and the effects were thought to be minimized by once-daily dosing. Prior elevations in serum CPK levels and/or myopathy have generally occurred at least 7 days after the initiation of therapy. WebDaptomycin is associated with a number of adverse effects including eosinophilic pneumonia, hypersensitivity reaction, myopathy, rhabdomyolysis, headache and transaminitis. The adverse effects of high-dose daptomycin have not been fully evaluated … inclusiveness meaning in bangla
Incidence of elevated creatine phosphokinase between …
WebJan 24, 2024 · Forest plots of incidence rates of elevated creatine phosphokinase (CPK) and rhabdomyolysis in patients treated with different daptomycin doses. (A) Forest plot showing the comparison of incidence rates of elevated CPK between the SD and HD groups. (B) Forest plot showing the comparison of rhabdomyolysis incidence between the SD and … WebOct 15, 2024 · Abstract. Background: Daptomycin-associated myopathy has been identified in 2%-14% of patients, and rhabdomyolysis is a known adverse effect. Although risk factors for daptomycin-associated myopathy are poorly defined, creatine phosphokinase (CPK) … WebDaptomycin is reported to cause an elevation in creatine kinase levels, although frank rhabdomyolysis is rare. An even more infrequent occurrence is the simultaneous development of acute kidney injury and drug-induced liver injury with rhabdomyolysis. Daptomycin and rifampin combination are used for synergistic bactericidal action against … inclusiveness means