Paclitaxel resistance

Author: qbug

August undefined, 2024

WebSep 29, 2024 · Paclitaxel (500 nM, Sigma), recombinant human IL-6 protein (R&D Systems, Minneapolis, MN, USA), IL-6R alpha antibody (R&D Systems, for in vitro use only), IL-6R alpha antibody (tocilizumab, for...

Paclitaxel Resistance Modulated by the Interaction between

WebJul 6, 2024 · Paclitaxel remained active in patients who had developed resistance to platinum-containing therapy (defined as tumor progression while on, or tumor relapse … WebApr 14, 2024 · Interestingly, miR-18a also promotes paclitaxel resistance in TNBC cells by hindering paclitaxel-induced apoptosis and suppressing the expression of Dicer, which is a processer for miRNA [231,232]. DICER promotes autophagy by inhibiting the activation of the PI3K/AKT/mTOR pathway and thus leads to cisplatin resistance non-small cell lung … nipe newborn

Effect of circHIPK3 on PTX resistance of Breast Cancer. CMAR

WebDec 16, 2024 · Paclitaxel has been used widely to treat breast cancer and other types of cancer. However, resistance is a major cause of failure for treatment and results in … WebOct 9, 2024 · Abstract We investigated the molecular mechanisms of paclitaxel resistance in TNBC using seven patient-derived xenograft (PDX) models and TNBC cell lines. Among the seven PDX models, four models showed resistance to paclitaxel. Dysregulation of JAK/STAT pathways and JAK2 copy number gains were observed in the four paclitaxel … WebWe conducted a phase II trial to evaluate the safety and efficacy of weekly paclitaxel in patients with resistant or relapsed non-small cell lung cancer (NSCLC) treated with docetaxel and carboplatin. Thirty-two NSCLC patients at a median age of 58.0 years (range 33-75) were enrolled. The Eastern Co … niper application form 2022

TLR4 Is a Novel Determinant of the Response to Paclitaxel in …

Aneuploidy increases resistance to chemotherapeutics by ... - PNAS

WebApr 27, 2024 · Identification of ALDH2 as a paclitaxel resistance-related gene in NSCLC cells. We first measured the resistance index (RI) value of the NSCLC/PTX cells to confirm PTX resistance. Results showed that the PTX resistance index of NSCLC/PTX cells is greater than 15 (Fig. S1A). Thus, the cells are highly drug-resistant and can be used in … WebPaclitaxel (PTX), a tubulin-binding agent, is widely used and has shown good efficacy in the initial period of treatment for non-small cell lung cancer (NSCLC). However, the relatively rapid acquisition of resistance to PTX treatments that is observed in virtually all cases significantly limits its … niper ahmedabad recruitment 2022WebFeb 27, 2006 · Abstract. Resistance to paclitaxel-based therapy is frequently encountered in the clinic. The mechanisms of intrinsic or acquired paclitaxel resistance are not well … numbers 2 nlt

"WebApr 23, 2024 · Paclitaxel, the most commonly used form of chemotherapy, is utilized in curative protocols in different types of cancer. The response to treatment differs among … " - Paclitaxel resistance

Paclitaxel resistance

Identified the novel resistant biomarkers for taxane …

WebMuch like paclitaxel resistance, a delay in G1 is likely to confer resistance by limiting entry into S phase in the presence of cisplatin, which will greatly reduce cisplatin’s ability to damage DNA. However, G1 delay-induced resistance to cisplatin may go beyond whether or not a cell enters S phase in the presence of the drug; our data ... WebAug 23, 2024 · Platinum plus paclitaxel is a first-line chemotherapy for ovarian cancer. Platinum resistance is a hot topic for many scholars, but drug resistance caused by paclitaxel is also a topic of concern. Currently, scholars believe that inhibition of MAPK signaling pathway may be an effective way to reverse the drug resistance of tumor …

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Web58 rows · BMS-184476 is a novel taxane (methylthiomethyl ether of paclitaxel) active … WebPaclitaxel (PTX) is a first-line drug for late-stage non-small cell lung cancer (NSCLC) patients who do not benefit from targeted therapy or immunotherapy. However, patients invariably develop resistance to PTX upon prolonged treatments. Although diverse mechanisms leading to PTX resistance have bee …

WebIntroduction. Breast cancer (BC) remains the most common type of cancer among women. 1 Paclitaxel (PTX), a type of chemotherapeutic drug taxanes, is an antineoplastic drug, … WebPaclitaxel has been widely used as an anti-mitotic agent in chemotherapy for a variety of cancers and adds substantial efficacy as the first-line chemotherapeutic regimen for …

WebAn understanding of the mechanisms of intrinsic or acquired resistance of cancer cells to paclitaxel can result in (1) design of better therapeutic modalities (drug combinations, … WebAug 8, 2013 · To test whether paclitaxel -induced inflammatory responses protect cells from chemotherapy, we measured IC 50 of paclitaxel in TLR4 + MDA-MB-231 and TLR4-negative HCC1806 cells. As shown in Fig. 2A and B, TLR4 + MDA-MB-231 was 4-fold more resistant to paclitaxel as compared with HCC1806 (IC 50 of 12.5 vs.3.25 nmol/L; P = …

WebSep 1, 2024 · Paclitaxel Docetaxel Epithelial-to-mesenchymal transition (EMT) Drug resistance Chemoresistance Metastasis 1. Introduction Over the recent years, a …

WebMar 15, 2024 · Methods. The in vitro treatment effect on cell viability was assayed using CCK8 kit, cell morphological change was detected by β-tubulin immunofluorescence … niper 2022 application formWebMar 25, 2024 · Paclitaxel is a first line chemotherapeutic agent for the patients with metastatic breast cancer. But inherited or acquired resistance to paclitaxel leads to … niper ahmedabad instrument facilityWebNov 11, 2024 · Paclitaxel is a chemotherapeutic agent that acts as an inhibitor of cellular mitosis and has been widely used in the treatment of triple-negative breast cancer … niper application form 2023WebAug 4, 2024 · Conventional frontline treatment for ovarian cancer consists of successive chemotherapy cycles of paclitaxel and platinum. Despite the initial favorable responses … nipe referral pathwaysWebNov 24, 2024 · Cells with paclitaxel resistance were constructed by gradually increasing paclitaxel concentration. Among the four cell lines, MCF-7 and MDA-MB-231 grew relatively well under the action of paclitaxel; these drug-resistant cell lines were named MDA-MB-231-PR and MCF-7-PR. numbers 2 logoWebOct 21, 2024 · PTX resistance mechanisms are different and involve alterations in α- and β-tubulin, increased expression and activity of multidrug resistance (MDR) efflux … niper application formWebA TPGS-incorporating nanoemulsion of paclitaxel circumvents drug resistance in breast cancer. Int J Pharm. 2014;471(1–2):206–213. 38. Chen F, Wu J, Zheng C, et al. TPGS modified reduced bovine serum albumin nanoparticles as a lipophilic anticancer drug carrier for overcoming multidrug resistance. niper cut off