Phosphodegron是什么意思
WebJul 12, 2024 · 通常而言,SCF通过识别底物蛋白上被磷酸化修饰后的特定结构域(也称作磷酸化降解结构域,“phosphodegron”),从而泛素化底物后进行降解。 WebDec 24, 2024 · Temperature compensation is a critical feature of circadian rhythms, but how it is achieved remains elusive. Here, we uncovered the important role played by the Drosophila PERIOD (PER) phosphodegron in temperature compensation. Using CRISPR-Cas9, we introduced a series of mutations that altered three Serines (S44, 45 and 47) …
Phosphodegron是什么意思
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Web年 月 马文建,等:Degron——细胞蛋白的快速降解及可逆调控技术 ·3· rescent protein,deGradFP)、小分子辅助开关(small WebAug 13, 2008 · Phosphodegron recognition by SCF Cdc4. F-box proteins (FBPs) are the substrate-specificity subunits of the multisubunit SCF family of E3 ligases, which contains …
WebOct 7, 2005 · The elucidation of the Skp2 structure complexed with its cofactor Cks1 and bound to a phosphopeptide corresponding to the phosphodegron of the SCF Skp2 substrate p27 Kip1 (Hao et al. [2005], this issue of Molecular Cell) resolves several key structure-function issues but, intriguingly, raises a number of new questions to ponder. WebThe phosphodegron-mediated degradation and the Ser 127 phosphorylation-dependent translocation coordinately suppress YAP oncogenic activity. Our study identified CK1δ/ɛ as new regulators of YAP and uncovered an intricate mechanism of YAP regulation by the Hippo pathway via both S127 phosphorylation-mediated spatial regulation (nuclear ...
Webphosphodegron的中文翻译,phosphodegron是什么意思,怎么用汉语翻译phosphodegron,phosphodegron的中文意思,phosphodegron的中文,phosphodegron in Chinese,phosphodegron的中文,phosphodegron怎么读,发音,例句,用法和解释由查查在线词典提供,版权所有违者必究。 WebSep 29, 2024 · phosphodegron (plural phosphodegrons) A phosphorylated degron 2015 October 27, “Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 …
WebRecognition of Phosphodegron Motifs in Human Cyclin E by the SCFFbw7 Ubiquitin Ligase* Received for publication, August 11, 2004, and in revised form, September 9, 2004 …
http://www.ichacha.net/phosphodegron.html florist west chester paWebThe Hippo tumor suppressor pathway plays a major role in development and organ size control, and its dysregulation contributes to tumorigenesis. TAZ (transcriptional co-activator with PDZ-binding motif; also known as WWTR1) is a transcription co-activator acting downstream of the Hippo pathway, and increased TAZ protein levels have been … florist west byfleet surreyhttp://xuebao.tust.edu.cn/docs/2024-09/20240920241328422656.pdf florist western springs illinoisWebJul 7, 2012 · TAZ contains another phosphodegron in its N-terminal region that also matches the β-TrCP recognition sequence DSGXXS and is adjacent to the LATS phosphorylation site Ser-66 (Fig. 3 B). Phosphorylation of Ser-66 by LATS could provide the priming phosphorylation for subsequent phosphorylation of Ser-62 and Ser-58 by GSK3β … greece professional basketballWebphosphodegron是什么意思,磷酸化降解决定子翻译-生物医药大词典. 您现在的位置: 生物医药大词典 >> 通用词典 >> 词汇解释: phosphodegron. phosphodegron. 分享到:. 磷酸化 … florist westfield kotarahttp://endo.dxy.cn/article/62891 florist west end north carolinaWeb(Cdc4) phosphodegron (CPD), a consensus motif for ubiquity-lation by Fbw7, which includes Thr176. Ectopic expression of Fbw7 destabilized GATA2 and promoted its proteasomal deg-radation. Substitution of threonine 176 to alanine in GATA2 inhibitedbindingwithFbw7,andtheubiquitylationanddegra-dation of GATA2 by Fbw7 was … greeceprobaseball